As a woman scientist, Elizabeth R Simons, PhD, was a pioneer, performing cutting edge biochemistry research, running a large research laboratory at Harvard Medical School and then moving on to become a full professor at Boston University School of Medicine where she spent 40 years. Her career was marked by an amazing record in teaching, grant awards, and publications while crusading for equal opportunities and pay for women teaching and conducting research in academia. Liz inspired many young scientists, including generations of women whom she mentored to balance success in science with a fulfilling family life. When they faltered, she was always there to lend an ear, a word of advice or even the voice of reason, for which they continue to be grateful. Born in 1929, Liz was the only female in her graduating class at Cooper Union in 1950 to earn a Bachelor of Chemical Engineering. In 1953 she earned a PhD in Physical Chemistry from Yale University, which is where she met her husband Harold Simons (deceased 1999), who also earned his PhD in Physical Chemistry at Yale. Liz deftly balanced her career and family. She is survived by her daughter Lee Simons Mulert (Mark) and son Bob Simons (Patrice) as well as her five grandchildren, Claire and Kevin Mulert and Wesley, Josh & Drew Simons, all of whom she loved dearly, and by her beloved dog Lulu. Liz passed away peacefully in Newton, MA on March 25, 2019 surrounded by her family.